Rancho La Sierra (also called "La Sierra de Santa Ana") was a 17,774-acre (71.93 km2) Mexican land grant in present-day Riverside County, California, United States. In 1846 Governor Pio Pico issued the grant to Vicenta Sepulveda. The rancho includes the present-day city of Norco, and the western end of Riverside.
Maria Vicenta Sepulveda (1816–1907) was a daughter of Francisco Sepulveda, recipient of the Rancho San Vicente y Santa Monica land grant. Vicenta married Tomas Antonio Yorba (1788–1845) in 1834. Tomas was a son of José Antonio Yorba, the grantee of Rancho Santiago de Santa Ana in present-day Orange County. Tomas, along with some of his brothers, pastured animals on lands east of their father's Rancho Santiago de Santa Ana, and in 1834 his brother Bernardo Yorba requested, and was granted, Rancho Cañón de Santa Ana. Tomas and Bernardo continued to pasture lands even further east, in an area they had named La Sierra.
In 1845, after Tomas had died, Bernardo applied for four square leagues of the La Sierra lands. Nine days later Vicenta Sepulveda, then a widow and going by her maiden name, also applied for some of the same La Sierra lands. On June 15, 1846 Governor Pio Pico granted the east half of the lands, Rancho La Sierra (Sepulveda), to Vicente Sepulveda, and the west half, Rancho La Sierra (Yorba) to Bernado Yorba. Vicenta married Jose Ramon Carrillo (1821–1864) in 1847.
With the cession of California to the United States following the Mexican-American War, the 1848 Treaty of Guadalupe Hidalgo provided that the land grants would be honored. As required by the Land Act of 1851, a claim for Rancho La Sierra was filed with the Public Land Commission in 1852, and the grant was patented to Vicenta Sepulveda in 1877.