RNase III
| Ribonuclease III domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ribonuclease III structure interacting with double stranded RNA.
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| Identifiers | |||||||||
| Symbol | RNase_III | ||||||||
| Pfam | PF00636 | ||||||||
| InterPro | IPR000999 | ||||||||
| PROSITE | PDOC00448 | ||||||||
| SCOP | 1jfz | ||||||||
| SUPERFAMILY | 1jfz | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Ribonuclease III (RNase III or RNase C)(BRENDA 3.1.26.3) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations to transform them into mature RNAs. These enzymes are a group of endoribonucleases that are characterized by their ribonuclease domain, which is labelled the RNase III domain. They are ubiquitous compounds in the cell and play a major role in pathways such as RNA precursor synthesis, RNA Silencing, and the pnp autoregulatory mechanism.
Within the RNase III superfamily, there are four known classes: 1, 2, 3, and 4. Each class is defined by both its functional and structural differences.
Class 1 RNase III
Class 2 RNase III
Class 3 RNase III
Class 4 RNase III
This article incorporates text from the public domain Pfam and InterPro IPR000999
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