Quinupristin-dalfopristin
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Quinupristin (top) and dalfopristin (bottom)
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| Quinupristin | Streptogramin antibiotic |
| Dalfopristin | Streptogramin antibiotic |
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IV |
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Quinupristin/dalfopristin (pronunciation: kwi NYOO pris tin / dal FOE pris tin) (trade name Synercid) is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.
Quinupristin and dalfopristin are both streptogramin antibiotics, derived from pristinamycin. Quinupristin is derived from pristinamycin IA; dalfopristin from pristinamycin IIA. They are combined in a weight-to-weight ratio of 30% quinupristin to 70% dalfopristin.
Intravenous, usually 7.5 mg/kg every 8–12 hours
Quinupristin and dalfopristin are protein synthesis inhibitors in a synergistic manner. While each of the two is only a bacteriostatic agent, the combination shows bactericidal activity.
Clearance by the liver, half-life 1–3 hours (with persistence of effects for 9–10 hours).
The drug inhibits P450 and enhances the effects of terfenadine, astemizole, indinavir, midazolam, calcium channel blockers, warfarin, cisapride and ciclosporin.
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