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Quinoline Yellow WS

Quinoline Yellow WS
Quinoline Yellow WS.svg
Names
IUPAC name
Sodium 2-(1,3-dioxoindan-2-yl)quinolinedisulfonate
Other names
C.I. Acid Yellow 3, Food Yellow 13, D&C Yellow No. 10, Acid yellow 3, Quinidine Yellow KT, Japan Yellow 203, Lemon Yellow ZN 3, C.I. 47005
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.116.526
EC Number 305-897-5
E number E104 (colours)
PubChem CID
UNII
Properties
C18H13NO5/8/11S1/2/3Na1/2/3
Molar mass 477.38 g/mol
Appearance Greenish yellow powder
Melting point 150 °C (302 °F; 423 K) (decomposes)
Soluble
Acidity (pKa) 1.8
Hazards
Main hazards Harmful (Xn)
R-phrases R22
S-phrases S24/25, S28, S37, S45
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

Quinoline Yellow WS is a mixture of organic compounds derived from the dye Quinoline Yellow SS (Spirit Soluble). Owing to the presence of sulfonate groups, the WS dyes are water soluble (WS). It is a mixture of disulfonates (principally), monosulfonates and trisulfonates of 2-(2-quinolyl)indan-1,3-dionewith a maximum absorption wavelength of 416 nm.p. 119

Quinoline Yellow is used as a greenish yellow food additive in certain countries, designated in Europe as the E number E104. In the EU and Australia, Quinoline Yellow is permitted in beverages and is used in foods, like sauces, decorations, and coatings; Quinoline Yellow is not listed as a permitted food additive in Canada or the US, where it is permitted in medicines and cosmetics and is known as D&C Yellow 10. The Codex Alimentarius does not list it.

Quinoline Yellow WS has not been associated with any significant long-term toxicity, is not genotoxic or carcinogenic and there is no evidence of adverse effects on reproduction or development. Food colorants in general have been the subject of much scrutiny for their effect on health.

Since the 1970s and the well-publicized advocacy of Benjamin Feingold, there has been public concern that food colorings may cause ADHD-like behavior in children. These concerns have led the U.S. FDA and other food safety authorities to regularly review the scientific literature, and led the UK FSA to commission a study by researchers at Southampton University of the effect of a mixture of six food dyes (Tartrazine, Allura Red, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow FCF and Carmoisine (dubbed the "Southampton 6")) and sodium benzoate (a preservative) on children in the general population, who consumed them in beverages; the study published in 2007. The study found "a possible link between the consumption of these artificial colours and a sodium benzoate preservative and increased hyperactivity" in the children; the advisory committee to the FSA that evaluated the study also determined that because of study limitations, the results could not be extrapolated to the general population, and further testing was recommended".


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