Charlotte of Mecklenburg-Strelitz (Sophia Charlotte; 19 May 1744 – 17 November 1818) was the wife of King George III. She was Queen of Great Britain and Ireland from her marriage in 1761 until the union of the two kingdoms in 1801, after which she was Queen of the United Kingdom of Great Britain and Ireland until her death in 1818. She was also the Electress of Hanover in the Holy Roman Empire until the promotion of her husband to King of Hanover on 12 October 1814, after which she was also queen consort of Hanover.

Queen Charlotte was a patroness of the arts and an amateur botanist, who helped expand Kew Gardens. George III and Charlotte had 15 children, 13 of whom survived to adulthood. She was distressed by her husband's bouts of physical illness and insanity, which became permanent in later life and resulted in their eldest son being appointed Prince Regent in 1811.

Sophia Charlotte was born on 19 May 1744. She was the youngest daughter of Duke Charles Louis Frederick of Mecklenburg-Strelitz, Prince of Mirow and his wife Princess Elizabeth Albertine of Saxe-Hildburghausen. Mecklenburg-Strelitz was a small north German duchy in the Holy Roman Empire.

The children of Duke Charles were all born at the Untere Schloss (Lower Castle) in Mirow. According to diplomatic reports at the time of her engagement to George III, Charlotte had received "a very mediocre education".

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