prostaglandin-E synthase | |||||||||
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human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW
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Identifiers | |||||||||
EC number | 5.3.99.3 | ||||||||
CAS number | 52227-79-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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Search | |
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PMC | articles |
PubMed | articles |
NCBI | proteins |
prostaglandin E synthase (microsomal) | |
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Identifiers | |
Symbol | PTGES |
Alt. symbols | MGST1L1 |
Entrez | 9536 |
HUGO | 9599 |
OMIM | 605172 |
RefSeq | NM_004878 |
UniProt | O14684 |
Other data | |
Locus | Chr. 9 q34.3 |
prostaglandin E synthase 2 (microsomal) | |
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Identifiers | |
Symbol | PTGES2 |
Alt. symbols | C9orf15 |
Entrez | 80142 |
HUGO | 17822 |
OMIM | 608152 |
RefSeq | NM_198939 |
UniProt | Q9H7Z7 |
Other data | |
Locus | Chr. 9 q34.12 |
prostaglandin E synthase 3 (cytosolic) | |
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Identifiers | |
Symbol | PTGES3 |
Alt. symbols | p23, TEBP, cPGES |
Entrez | 10728 |
HUGO | 16049 |
OMIM | 607061 |
RefSeq | NM_006601 |
UniProt | Q15185 |
Other data | |
Locus | Chr. 12 q13.13 |
Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.
The synthase generating PGE2 is a membrane-associated protein.
Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene: