Probucol

Probucol

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a611037
ATC code	C10AX02 (WHO)
Identifiers
IUPAC name 4,4'-[propane-2,2-diylbis(thio)]bis(2,6-di-tert-butylphenol)
Synonyms	2,6-di-tert-butyl-4-({2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]propan-2-yl}sulfanyl)phenol
CAS Number	23288-49-5 Y
PubChem CID	4912
IUPHAR/BPS	7277
DrugBank	DB01599 Y
ChemSpider	4743 Y
UNII	P3CTH044XJ
KEGG	D00476 Y
ChEBI	CHEBI:8427 N
ChEMBL	CHEMBL608 Y
ECHA InfoCard	100.041.404
Chemical and physical data
Formula	C31H48O2S2
Molar mass	516.844 g/mol
3D model (Jmol)	Interactive image
SMILES S(c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)C(Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)(C)C
InChI InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3 Y Key:FYPMFJGVHOHGLL-UHFFFAOYSA-N Y
NY (what is this?)

Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease.

However, clinical trials were stopped after it was found that it may lower HDL in patients with a previous history of heart disease.

Probucol was initially developed in the 1970s by a chemical company to maximize airplane tire longevity. Probucol is associated with QT interval prolongation.

Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.

It is believed to act at ABCA1.

It also lowers levels of HDL.