Princess Sophie Maria Friederike Auguste Leopoldine Alexandrine Ernestine Albertine Elisabeth of Saxony, Duchess of Saxony (Full German name: Prinzessin Sophie Maria Friederike Auguste Leopoldine Alexandrine Ernestine Albertine Elisabeth von Sachsen, Herzogin zu Sachsen) (15 March 1845, Dresden, Kingdom of Saxony – 9 March 1867, Munich, Kingdom of Bavaria) was the eighth and youngest child of John of Saxony and his wife Amalie Auguste of Bavaria and a younger sister of Albert of Saxony and George of Saxony. Through her marriage to Duke Karl-Theodor in Bavaria, Sophie was a member of the House of Wittelsbach and a Duchess in Bavaria.

Sophie married Duke Karl-Theodor in Bavaria, fifth child and third-eldest son of Duke Maximilian Joseph in Bavaria and his wife Princess Ludovika of Bavaria, on 11 February 1865 in Dresden. Sophie and Karl-Theodor had one child:

Childbirth caused severe respiratory problems for Sophie, which progressively weakened her, although she managed to recover. However, a year later she contracted a severe case of influenza that she could not overcome. Sophie died shortly before her 22nd birthday on 9 March 1867 and was interred at Tegernsee Abbey.

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