Princess Marie of Saxe-Weimar-Eisenach (3 February 1808 in Weimar – 18 January 1877 in Berlin) was a princess of Saxe-Wiemar-Eisenach, by birth, and, by marriage, a princess of Prussia. She was the daughter of Charles Frederick, Grand Duke of Saxe-Weimar-Eisenach and Grand Duchess Maria Pavlovna of Russia.

Princess Marie was the eldest daughter of Prince, and later Grand Duke, Charles Frederick of Saxe-Weimar-Eisenach and his wife, Grand Duchess Maria Pavlovna, who was the sister of Emperor Alexander I of Russia. Her father was a shy man, whose favourite reading material were fairy tales until the end of his life. Her mother, by contrast, was "one of the most significant woman of her time", according to Johann Wolfgang von Goethe. Marie and her three years younger sister Augusta, who became German Empress, received a comprehensive education, which focused on the courtly ceremonial duties they were to have as adults. This education included painting lessons by the court painter Louise Seidler and music lessons by the court conductor Johann Nepomuk Hummel.

Marie grew up at the court in Weimar, which was considered one of the most liberal in Germany. Saxe-Weimar-Eisenach had already adopted a constitution in 1816. The court was very receptive towards literature and other art forms, due to the influence of the late Duchess Anna Amalia, who had died in 1807. Goethe had been managing the court theater in Weimar until 1817 and remained a welcome guest at the ducal court afterwards.

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