Princess Marie of Prussia (Marie Elisabeth Louise Frederika of Prussia; 14 September 1855, Marmorpalais, Potsdam – 20 June 1888, Dresden), was a princess of the House of Hohenzollern. She was the daughter of Prince Frederick Charles of Prussia and later became second wife of Prince Henry of the Netherlands then the first wife of Prince Albert of Saxe-Altenburg. She was also the great-niece of Wilhelm I, German Emperor.

Princess Marie was the eldest daughter of Prussian field-marshal Prince Frederick Charles of Prussia (1828–1885) and his wife, Princess Maria Anna of Anhalt-Dessau (1837–1906). Marie's mother was the youngest daughter of Leopold IV, Duke of Anhalt and Princess Friederike of Prussia.

On 23 August 1878 Princess Marie married Prince Henry of Orange-Nassau at the Neuen Palais (1820–1879), who had since 1850 been Governor of Luxembourg and Admiralleutnant zur See. He was the third son of the King William II of the Netherlands and his wife Grand Duchess Anna Pavlovna of Russia. The marriage between Marie and Henry was arranged in an attempt to save the House of Orange-Nassau from extinction. Unfortunately, it was to prove childless: barely five months later, in January 1879, Prince Henry died after contracting measles.