Princess Louise of Saxe-Gotha-Altenburg,German: Luise, Prinzessin von Saxe-Gotha-Altenburg (born 9 March 1756 in Roda, Duchy of Saxe-Gotha-Altenburg; died 1 January 1808 at Schloss Ludwigslust in Ludwigslust, Duchy of Mecklenburg-Schwerin) was Duchess consort of Mecklenburg-Schwerin through her marriage to Frederick Francis I, Grand Duke of Mecklenburg, Louise was also a member of the House of Mecklenburg.

Louise was the fourth and youngest child of Prince John August of Saxe-Gotha-Altenburg and Countess Louise Reuss of Schleiz. After the death of her mother in 1773, both she and her older sister Augusta inherited the title of co-Countess of Limpurg-Gaildorf as one of the several heirs of William Henry, Schenk of Limpurg zu Gaildorf (d. 1690 without surviving male issue). Both sisters retained their portions of the Limpurg-Gaildorf inheritance (1/4 of Amt Gaildorf and 1/16 of the town of Gaildorf) until 1780, when they sold their share to Charles Eugene, Duke of Württemberg.

In Gotha on 1 June 1775, Louise married Frederick Francis, Hereditary Duke of Mecklenburg-Schwerin, eldest child and only son of Duke Ludwig of Mecklenburg-Schwerin and his wife Princess Charlotte Sophie of Saxe-Coburg-Saalfeld. They had six children:

...
Wikipedia