Princess Eleonore Erdmuthe Louise of Saxe-Eisenach (13 April 1662 – 9 September 1696), was a German princess member of the House of Wettin and through her two marriages was Margravine of Brandenburg-Ansbach (from 1681 to 1686) and Electress of Saxony (from 1692 to 1694).

Eleonore Erdmuthe Louise was the eldest child of John George I, Duke of Saxe-Eisenach, and Johannetta of Sayn-Wittgenstein. From her seven younger siblings, only four survive adulthood: Frederick August, Hereditary Prince of Saxe-Eisenach, John George II, Duke of Saxe-Eisenach, John William III, Duke of Saxe-Eisenach and Fredericka Elisabeth (by marriage Duchess of Saxe-Weisselfels).

In Eisenach on 4 November 1681, Eleonore married firstly John Frederick, Margrave of Brandenburg-Ansbach as his second wife. They had three children:

After the death of her husband (22 March 1686), the government of Brandenburg-Ansbach passed to her stepson Christian Albert (eldest surviving son of her husband's first marriage), who being a minor ruled under a regency. Because her relationship with her stepchildren wasn't good since the beginning, Eleonore and her children moved to Crailsheim, where they lived in poverty; shortly after, she returned alone to her homeland Eisenach, while her children were sent to Berlin, where they became companions of the together with Frederick William, Electoral Prince of Brandenburg. In November 1691 Eleonore also arrived in Berlin to actively participate in the negotiations of her second marriage.

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