Primera División de Fútbol Profesional Clausura 2001
| Champions | C.D. Aguila (13th title) |
|---|---|
| Relegated | C.D. San Luis |
| Top goalscorer |
 TBD (12) |
The Primera División de Fútbol Profesional Clausura 2001 season (officially "Torneo Clausura 2001") started on February 3, 2001, and finished on June 30, 2001.
The season saw C.D. Águila win its 13th league title after a 2–1 victory over C.D. FAS in the final.
It was also the last time El Salvador used promotion and relegation on a per-season basis. This saw C.D. San Luis become the last team to be relegated to the Segunda División de Fútbol Salvadoreño after competing in the first division for under six months. As of the following tournament (Apertura 2001), promotion and relegation were changed to once a year, and decided on aggregate points over both Apertura and Clausura seasons.
Santa Clara sold their spot to San Luis for 75, 000 dollars.
Promoted from Segunda División de Fútbol Salvadoreño as of February 3, 2001.
Relegated to Segunda División de Fútbol Salvadoreño as of June 30, 2001.
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