"Manuscript" is a broad concept in publishing, that can about one or both:
A manuscript is the work that an author submits to a publisher, editor, or producer for publication. Even with the advent of desktop publishing, making it possible for anyone to prepare text that appears professionally typeset, many publishers still require authors to submit manuscripts within their respective guidelines.
Although publishers guidelines for formatting are the most critical resource for authors,style guides are also key references for authors preparing manuscripts since "virtually all professional editors work closely with one of them in editing a manuscript for publication."
Manuscript formatting (also named standard manuscript format) depends greatly on the type of work that is being written, as well as the individual publisher, editor or producer. Writers who intend to submit a manuscript should determine what the relevant writing standards are, and follow them. Individual publishers' standards will take precedence over style guides.
In academic publishing, a preprint is a version of a scholarly or scientific paper that precedes publication in a peer-reviewed scholarly or scientific journal. The preprint may be available, often as a non-typeset version available free, before and/or after a paper is published in a journal.
Publication of manuscripts in a peer-reviewed journal often takes weeks, months or even years from the time of initial submission, owing to the time required by editors and reviewers to evaluate and critique manuscripts, and the time required by authors to address critiques. The need to quickly circulate current results within a scholarly community has led researchers to distribute documents known as preprints, which are manuscripts that have yet to undergo peer review. They may be considered as grey literature. The immediate distribution of preprints allows authors to receive early feedback from their peers, which may be helpful in revising and preparing articles for submission.