Prairie Hill is an unincorporated community in eastern Chariton County, Missouri, United States. It is located about eight miles northeast of Salisbury.
A post office called Prairie Hill was established in 1869, and remained in operation until 1966. The community was named for its elevated location upon a prairie.
Coordinates: 39°31′07″N 92°44′17″W / 39.51861°N 92.73806°W