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Postorgasmic illness syndrome

Postorgasmic illness syndrome
Classification and external resources
Specialty Andrology, Allergy, Endocrinology
MeSH D004542, D012735
Orphanet 279947
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Postorgasmic illness syndrome (POIS) is a syndrome in which men have severe cognitive and physical symptoms immediately following ejaculation in the absence of a local genital reaction. The symptoms last for up to a week. The cause and prevalence are unknown; it is considered a rare disease.

The distinguishing characteristics of POIS are:

POIS symptoms, which are called a "POIS attack", can include some combination of the following: cognitive dysfunction, aphasia, severe muscle pain throughout the body, severe fatigue, weakness, and flu-like or allergy-like symptoms, such as sneezing, itchy eyes, and nasal irritation. Additional symptoms include intense discomfort, irritability, anxiety, craving for relief, susceptibility to nervous system stresses (e.g. common cold), depressed mood, and difficulty communicating, remembering words, reading and retaining information, concentrating, and socializing. Affected individuals may also experience intense warmth or cold.

The symptoms begin shortly after or within a half hour of ejaculation.

The symptoms can last for several days, sometimes up to a week.

In some men, the onset of POIS is in puberty, while in others, the onset is in their twenties. POIS that is manifest from the first ejaculations in adolescence is called primary type; POIS that starts later in life is called secondary type.

Many POIS sufferers report lifelong premature ejaculation, with intravaginal ejaculation latency time (IELT) of less than one minute.

POIS has been called by a number of other names, including "postejaculatory syndrome", "postorgasm illness syndrome", "post ejaculation sickness", and "post orgasmic sick syndrome".

Dhat syndrome is a condition, first described in 1960 in India, with symptoms similar to POIS. Dhat syndrome is thought to be a culture-bound psychiatric condition and is treated with cognitive behavioral therapy along with anti-anxiety and antidepressant drugs.


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