Plymouth Friary railway station was the London and South Western Railway (LSWR) terminus in Plymouth, Devon, England.
London and South Western Railway trains first arrived at Plymouth on 17 May 1876, entering the town from the east. To get there trains had travelled over the company's line as far as Lydford railway station, then over the Great Western Railway (GWR) via and the South Devon main line to Mutley. They then continued over the new Cornwall Loop Viaduct (now known as Pennycomequick Viaduct) and a short section of the Cornwall Railway before reaching the company's line to its Devonport station. A new joint LSWR and GWR station at Plymouth North Road, a short distance to the west of Mutley, was opened on 28 March 1877.
Friary Goods Station had opened on 1 February 1878 at the end of a short branch from Friary Junction near Laira on the GWR's Sutton Harbour branch. On 22 October 1879 an extension was opened through a short tunnel beneath Exeter Street to North Quay on Sutton Harbour, from where wagon turntables allowed access to Sutton Wharf and Vauxhall Quay. A reversal at Friary allowed access to another branch to Cattedown, although this was not completed until 1888.
The LSWR established a route to Plymouth independent of the GWR on 1 June 1890, when the Plymouth, Devonport and South Western Junction Railway (PDSWJ) was opened from Lydford to Devonport. For a short while LSWR trains terminated at North Road, but on 1 July 1891 a new passenger terminus station was opened at Friary. The station was close to the eastern side of the town centre, facing onto Beaumont Road but also with an entrance from Exeter Street. There were four platform lines serving two platforms. A 300 feet (91 m) by 100 feet (30 m) goods shed was situated to the south of the station, the side nearest Exeter Street.