"Play the Guitar" is a song by American hip hop recording artist B.o.B, featuring fellow American rapper André 3000. The song, produced by Salaam Remi, samples "Bo Diddley" as performed by Bo Diddley as well as "Fancy" as performed by Drake, Swizz Beatz and T.I.. It was recorded for his second studio album, Strange Clouds (2012), however failed to make the final cut.

Mack of Sound-Savvy was invited to the October 25th listening session at Tree Sound Studios. B.o.B played 8 songs from the album for a private audience, then sat down with Mack of Sound-Savvy to talk about the new album. One of the tracks premiered was "Play the Guitar", B.o.B’s ode to his instrument of choice. He describes the song as one that expresses his "love for music and love for the guitar".

The song features André 3000, who rarely does guest appearances for other artists. Of the song, B.o.B says: "I feel like it shows people that we are two different artists and we actually do sound different and have our own styles. Not to say that I wasn’t influenced by Outkast and Andre, but I feel like it’s a ‘pass-the-torch’ type of moment. He really gave me a lot of love on the feature and I’m looking forward to hearing what people have to say about it.”

The song's hook features a sample of T.I.’s verse from Drake’s ‘Fancy’. B.o.B. introduced this one with his origins on playing the guitar, which he picked up after urges from his brother.

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