The Placidia Palace was the official residence of the papal apocrisiarius (the ambassador from the Pope to the Patriarch of Constantinople), and the intermittent home of the Pope himself when in residence at Constantinople. The apocrisiarius held "considerable influence as a conduit for both public and covert communications" between Pope and Byzantine emperor.
The residence of the apocrisiarius in the Placidia Palace dates to the end of the Acacian schism in 519. The ambassador was usually a deacon of Rome, and held an official position in the Byzantine imperial court. Anachronistically, the building can be referred to as the first nunciature.
The palace was built by Galla Placidia, near the ta Armatiou quarter in the tenth district of the city between the Gate of the Plataea and the Monastery of the Pantokrator.
The palace of Galla Placidia was one of several aristocratic residences (oikoi) built in the city's northwestern region during the late 4th and early 5th centuries. The tenth district included the palaces built by the Augusta Aelia Eudocia, the nobilissima Arcadia (sister of Theodosius II), while the nearby eleventh district included the house of Augusta Pulcheria and the Palace of Flaccilla (palataium Flaccillianum). These mansions formed a counterpart to the old-established aristocratic center of the eastern parts of the city, formed around the Great Palace; however, Most of these mansions in the northwestern districts seem to have been only in use as seasonal retreats.