Pike Creek is a stream in Carter and Shannon counties the Ozarks of southern Missouri. It is a tributary of the Current River.
The stream headwaters are in Shannon County at 37°00′06″N 91°23′57″W / 37.00167°N 91.39917°W and the confluence with the Current is in Carter County at 36°59′40″N 91°01′16″W / 36.99444°N 91.02111°WCoordinates: 36°59′40″N 91°01′16″W / 36.99444°N 91.02111°W.