Pietro Perna (1519 – August 16, 1582) was an Italian printer, the leading printer of Late Renaissance Basel, the Erasmian crossroads between Italian Renaissance humanism and the Protestant Reformation. His books promoted the Italian heretical thinkers at the origins of Socinianism and the theory of Tolerance. He was a major publisher of Protestant historians like Flacius Illyricus and David Chytraeus and promoted the ars historica treatises of the period, notably the 18 authores de historia in Artis Historicae Penus (1579).
A native of Lucca and a Dominican, he arrived in Basel in 1544 as a disciple of the reformer Pietro Martire Vermigli and with the help of Pietro Carnesecchi. As a printer he started as an assistant to the renowned Johannes Oporinus and set up a press of his own in 1558. As a bookseller and apprentice printer he established a network of Italian connections that helped him act as a go between and publisher of Italian reformed thinkers and writers, such as Vermigli, Pier Paolo Vergerio, Jacopo Aconcio, Bernardino Ochino, Lelio Sozzini, Sebastian Castellio, Celio Secondo Curione, etc. He published the editio princeps of the original Greek text of the Enneads of Plotinus. He produced important editions of Machiavelli and Bodin, Guicciardini and Lodovico Castelvetro. He published works of Paracelsus and various Paracelsians but also served as the chief printer of Paracelsus's leading critic Thomas Erastus. In 1570 Perna sent the artist Tobias Stimmer to Como to copy the famous collection of historical portraits in the Giovio Collection. Stimmer's distinctive woodcuts decorate numerous editions of Paolo Giovio, brought out by Perna and Heinrich Petri. The Basel doctor and polymath Theodor Zwinger was his close collaborator. Perna died of the plague and was buried in St. Peter's Church.