Piecemeal necrosis

Piecemeal necrosis generally refers to a necrosis that occurs in fragments.

Piecemeal necrosis in liver aka interface hepatitis is necrosis of the limiting plates. It may be identified as actual necrosis of cells or by irregularity of the limiting plates which is caused IOS's hepatocytes and replacement with inflammatory cells and/or fibrosis.

When used in relation to the liver, piecemeal necrosis (also termed troxis necrosis,nibbling necrosis and interface necrosis) refers specifically to a loss and degeneration of (limiting plate) hepatocytes at the lobular-portal-interface, producing a moth-eaten irregular appearance. Piecemeal necrosis of the liver is associated with a lymphocytic infiltrate into the adjacent parenchyma, and with destruction of individual hepatocytes along the edges of the portal tract.

It is a feature of viral hepatitis (especially chronic hepatitis) as well as autoimmune hepatitis and steatohepatitis.

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