Phillip Allen Sharp
| Phillip Sharp | |
|---|---|
With Winthrop-Sears Medal, 2007
|
|
| Born | Phillip Allen Sharp June 6, 1944 Falmouth, Kentucky |
| Nationality | American |
| Fields | Biologist |
| Institutions | |
| Alma mater | |
| Doctoral students | |
| Notable awards |
|
| Spouse | Ann Holcombe |
|
Website web |
|
 |
|
 Meet Phillip Sharp: "What we were able to discover was that in human cells and in many other cells of higher-order organisms, the genes come in discontinuous segments", MIT
|
Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence". He has been selected to receive the 2015 Othmer Gold Medal.
Sharp's current research focuses on small RNAs and other types of non-coding RNAs. His laboratory works to identify the target mRNAs of microRNAs (miRNAs), and has discovered a class of miRNAs that are produced from sequences adjacent to transcription start sites. His laboratory also studies how miRNA gene regulation functions in angiogenesis and cellular stress.
Sharp was born in Falmouth, Kentucky, the son of Kathrin (Colvin) and Joseph Walter Sharp. Sharp married Ann Holcombe in 1964. They have three daughters.
Sharp studied at Union College and majored in chemistry and mathematics, afterwards completing his Ph.D. in chemistry at the University of Illinois at Urbana-Champaign in 1969. Following his Ph.D., he did his postdoctoral training at the California Institute of Technology until 1971, where he studied plasmids. Later, he studied gene expression in human cells at the Cold Spring Harbor Laboratory as a senior scientist under James Dewey Watson.
...
Wikipedia