Pennsboro is an unincorporated community in Dade County, in the U.S. state of Missouri.
Pennsboro was founded in the 1880s, and named after William Penn, a Dade County pioneer. A post office was established at Pennsboro in 1895, and remained in operation until 1931.
Coordinates: 37°19′38″N 93°50′03″W / 37.32722°N 93.83417°W