Panagia (Greek: Παναγία, fem. of panágios, pan- + hágios, the All-Holy; pronounced Greek pronunciation: [panaˈʝia] in Medieval and Modern Greek, also transliterated Panayia or Panaghia, is one of the titles of Mary, the mother of Jesus, used especially in Orthodox Christianity.
Most Greek churches dedicated to the Virgin Mary are called Panagia; the standard western Christian designation of "St. Mary" is rarely used in the Orthodox East, as Mary is considered the holiest of all human beings and therefore of higher status than the Saints.
Panagia is also the term for a particular type of icon of the Theotokos, wherein she is facing the viewer directly, usually depicted full length with her hands in the orans position, and with a medallion showing the image of Christ as a child in front of her chest. This medallion symbolically represents Jesus within the womb of the Virgin Mary at the moment of the Incarnation. This type of icon is also called the Platytéra (Greek: Πλατυτέρα, literally wider or more spacious): poetically, by containing the Creator of the Universe in her womb, Mary has become Platytera ton ouranon (Πλατυτέρα τῶν Ουρανῶν), "more spacious than the Heavens". This type is also sometimes called the Virgin of the Sign or Our Lady of the Sign, a reference to Isaiah 7:14:
Therefore the Lord himself shall give you a sign; Behold, a virgin shall conceive, and bear a son, and shall call his name Immanuel.
Such an image is often placed on the inside of the apse which rises directly over the altar of Orthodox churches. In contrast with standard religious mosaics which usually have gold backgrounds, the Platytera is often depicted on a dark blue background, sometimes dotted with gold stars: a reference to the Heavens.
As with most Orthodox icons of Mary, the letters ΜΡ ΘΥ (short for ΜΗΤΗΡ ΘΕΟΥ, "Mother of God") are usually placed on the upper left and right of the halo of the Virgin Mary.