Panagis Tsaldaris (1868 – 17 May 1936) (or Panagiotis Tsaldaris or Panayotis Tsaldaris, Greek: Παναγής Τσαλδάρης) was a Greek politician and the 48th Prime Minister of Greece; he was a revered conservative politician and leader for many years (1922–1936) of the conservative People's Party in the period before World War II. He was the husband of Lina Tsaldari, a Greek suffragist, member of Parliament, and the Minister for Social Welfare.
Tsaldaris was born in 1868 in Kamari, near Corinth in the Peloponnese. He studied in the Law School of the University of Athens and, being an excellent student, he continued his studies abroad, among other places in Berlin and Paris. After he returned to Greece, he worked as a lawyer. Because of his expertise as an advocate, he gained the respect of his colleagues.
In 1919, Tsaldaris married the daughter of the university professor (and later Prime Minister of Greece) Spyridon Lambrou, Lina Tsaldaris, who stood by him during all his life and remained politically active, even after her husband's death.
Tsaldaris entered politics in 1910, when he was elected for the first time to the Parliament for Corinth. He would be successively reelected to Parliament until his death in 1936. In 1915, he sided with King Constantine I in the latter's conflict with Eleftherios Venizelos (see national Schism) and became Minister of Justice in Dimitrios Gounaris's government. Nonetheless, after the return of Venizelos and the self-exile of the King in 1917, Panagis Tsaldaris was imprisoned and then exiled in various islands of the Aegean Sea.