Coordinates: 41°54′9.70″N 12°27′36.00″E / 41.9026944°N 12.4600000°E
The Palazzo Rusticucci-Accoramboni (also known as Palazzo Rusticucci or Palazzo Accoramboni) is a reconstructed late Renaissance palace in Rome. Erected by the will of Cardinal Girolamo Rusticucci, it was designed by Domenico Fontana and Carlo Maderno joining together several buildings already existing. Due to that, the building was not considered a good example of architecture. Originally lying along the north side of the Borgo Nuovo street, after 1667 the building faced the north side of the large new square located west of the new Saint Peter's Square, designed in those years by Gian Lorenzo Bernini. The square, named Piazza Rusticucci after the palace , was demolished in 1937–40 because of the erection of the new Via della Conciliazione. In 1940 the palace was dismantled and rebuilt with a different footprint along the north side of the new avenue, constructed between 1936 and 1950, which links St Peter's Basilica and the Vatican City to the center of Rome.
The palace is located in the Borgo rione of Rome along the north side of Via della Conciliazione avenue, its main facade facing south. It belongs to the same block as the Palazzo dei Convertendi, another Renaissance building demolished in the late 1930s and reconstructed in the 1940s east of it. To the west Via Rusticucci separates it from the north Propylaea delimiting the square Piazza Pio XII (which roughly occupies the same area as the old Piazza Rusticucci) and facing Saint Peter's Square. The north side of the building borders two other reconstructed Renaissance edifices of Borgo: the Palazzo Jacopo da Brescia and the house of the physician of Paul III.