The Oxford Philosophical Club refers to a group of natural philosophers, mathematicians, physicians, virtuosi and dilettanti gathering around John Wilkins FRS (1614–1672) at Oxford in the period 1649 to 1660. It is documented in particular by John Aubrey: he refers to it as an "experimental philosophical club" run weekly by Wilkins, who successfully bridged the political divide of the times. There is surviving evidence that the Club was formally constituted, and undertook some projects in Oxford libraries. Its historical importance is that members formed one of the major groups that came together in the early 1660s to form the Royal Society of London.
Wilkins was Warden of Wadham College, and the circle around him is also known as the Wadham Group, though it was not restricted to members of the College. It included William Petty, Jonathan Goddard and John Wallis from the 1645 group in London.
The term Oxford Philosophical Society may refer to this club, or at least two later societies.
A number of the Club's leading members showed a united front in opposition to Thomas Hobbes, from 1654, as they resisted external pressures for university reform. In the longer term the Hobbes-Wallis controversy developed out of the Vindiciae academiarum (1654) of Wilkins and Seth Ward. Generally Wilkins with Goddard and a few other allies were active on the traditionalist side of the debates on academia of the time, a point emphasised later by Thomas Sprat and Walter Pope, as well as trying to keep a calm approach on divisive issues. Wilkins and Ward sympathised with Puritan views, as followers of the line of John Conant, but not with the wish for open theological clashes. One of the aims of the group was in theology, however: to develop a natural philosophy which would be at the same time "mechanical" and providential.