Oxamniquine
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| Trade names | Vansil |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration |
by mouth |
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| Pharmacokinetic data | |
| Bioavailability | Readily absorbed when taken by mouth |
| Metabolism | liver |
| Biological half-life | 1 to 2.5h |
| Excretion | mainly in urine |
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| PDB ligand | |
| ECHA InfoCard | 100.040.491 |
| Chemical and physical data | |
| Formula | C14H21N3O3 |
| Molar mass | 279.3 |
| 3D model (Jmol) | |
| Chirality | Racemic mixture |
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Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to Schistosoma mansoni.Praziquantel; however, is often the preferred treatment. It is given by mouth and used as a single dose.
Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine. It is typically recommended that it not be used until after pregnancy if possible. Seizures may occur and therefore caution is recommended in people with epilepsy. It works by causes paralyses of the parasitic worms. It is in the anthelmintic family of medications.
Oxamniquine was first used medically in 1972. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is not commercially available in the United States. It is more expensive than praziquantel.
Oxamniquine is used for treatment of schistosomiasis. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective.
It is generally well tolerated following oral doses. Dizziness with or without drowsiness occurs in at least a third of patients, beginning up to three hours after a dose, and usually lasts for up to six hours. Headache and gastrointestinal effects, such as nausea, vomiting, and diarrhoea, are also common.
Allergic-type reactions, including urticaria, pruritic skin rashes, and fever, may occur. Liver enzyme values have been raised transiently in some patients. Epileptiform convulsions have been reported, especially in patients with a history of convulsive disorders. Hallucinations and excitement have occurred rarely.
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