Orthohepevirus

Orthohepevirus
Virus classification
Group:	Group IV ((+)ssRNA)
Order:	Unassigned
Family:	Hepeviridae
Genus:	Orthohepevirus
Type species
Orthohepevirus A
Species
Orthohepevirus A Orthohepevirus B Orthohepevirus C Orthohepevirus D

Orthohepevirus A Orthohepevirus B Orthohepevirus C Orthohepevirus D

Orthohepevirus is a genus of viruses assigned to the Hepeviridae family. Orthohepevirus is a fairly isolated viral genus in which the virions are characterized by round, non-enveloped and isometric capsids with a diameter of 27–34 nm. The type species is Orthohepevirus A, more commonly known as the Hepatitis E virus.

Orthohepevirus have RNA genomes of 7176 nucleotides in length and infect vertebrates. Additionally, the genome is monopartite, linear, and single-stranded. The genome is 5' capped with a poly A tail at the 3' end. The genome possesses three main open reading frames. The first encodes non-structural proteins, the second encodes the capsid proteins, and the third encodes a small, multifunctional protein.

Viruses from this genus have been isolated from birds and bats. The creation of new species within this genus to accommodate these viruses seems likely. At least three species of hepatitis E-like viruses have been isolated from birds.

A Hepatitis E-like virus has been isolated from a Swedish moose. This virus is quite distinct from the other known Hepatitis E viruses.

In total, the genus has four recognized species: Orthohepevirus A, Orthohepevirus B, which was previously known as the avian hepatitis E virus, Orthohepevirus C, and Orthohepevirus D.

A species has been isolated from a trout (Oncorhynchus clarkii). This species has been placed in a different genus—Piscihepevirus

Hepatitis E was first isolated in 1990. It was thought to be restricted to humans until 1997 when it was isolated from pigs. The first isolation from birds was in 2001.

One study has suggested that this species may have originated in birds and then spread to bats and other mammalian species.

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