Oponice (Hungarian: Appony) is a municipality in the Topoľčany District of the Nitra Region, Slovakia. In 2011 it had 879 inhabitants.
The name is derived from Slovak opona, oponica – "a cover", "a tent", in modern Slovak "a curtain" (Apon 1218, Opon 1315 – Veľké Oponice, Oponh 1300 – Malé Oponice). The name was probably motivated by a guard camp belonging to the neigbouring castle.
Coordinates: 48°28′N 18°09′E / 48.467°N 18.150°E