Omnaris

Ciclesonide

Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a607008
Pregnancy category	AU: B3 US: C (Risk not ruled out)
Routes of administration	Nasal inhalation
ATC code	R01AD13 (WHO) R03BA08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Identifiers
IUPAC name 2-[(1S, 2S, 4R, 8S, 9S,11S, 12S, 13R)-6-cyclohexyl-11-hydroxy-9, 13-dimethyl-16-oxo-5, 7-dioxapentacyclo [10.8.0.02,9.04, 8.013,18] icosa-14, 17-dien-8-yl]- 2-oxoethyl 2-methylpropanoate
Synonyms	(11β, 16α)-16, 17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21- (2-methyl-1-oxopropoxy)- pregna-1, 4-diene-3, 20-dione
CAS Number	126544-47-6 N
PubChem CID	6918155
IUPHAR/BPS	7469
DrugBank	DB01410 Y
ChemSpider	5293368 Y
UNII	S59502J185
KEGG	D01703 Y
ChEMBL	CHEMBL1201164 N
Chemical and physical data
Formula	C32H44O7
Molar mass	540.688 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(OCC(=O)[C@]25O[C@@H](O[C@@H]5C[C@H]1[C@H]4[C@H]([C@@H](O)C[C@@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)C6CCCCC6)C(C)C
InChI InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1 Y Key:LUKZNWIVRBCLON-GXOBDPJESA-N Y
NY (what is this?)

Ciclesonide is a glucocorticoid used to treat asthma and allergic rhinitis. It is marketed under the brand names Alvesco for asthma and Omnaris, Omniair, and Zetonna for hay fever in the US and Canada. Phase 3 trials for the hay fever indication outside of the US are ongoing. The drug was approved for adults and children 12 and over by the US Food and Drug Administration in October 2006. Side effects of the medication include headache, nosebleeds, and inflammation of the nose and throat linings.