The Congregation for the Doctrine of the Faith (Latin: Congregatio pro Doctrina Fidei, CDF) is the oldest among the nine congregations of the Roman Curia. It was founded to defend the church from heresy; today, it is the body responsible for promulgating and defending Catholic doctrine. Formerly known as the Supreme Sacred Congregation of the Roman and Universal Inquisition, it is informally known in many Catholic countries as the Holy Office, and between 1908 and 1965 was officially known as the Supreme Sacred Congregation of the Holy Office.
Founded by Pope Paul III in 1542, the congregation's sole objective is to "spread sound Catholic doctrine and defend those points of Christian tradition which seem in danger because of new and unacceptable doctrines." Its headquarters are at the Palace of the Holy Office, just outside Vatican City. The congregation employs an advisory board including cardinals, bishops, priests, lay theologians, and canon lawyers. The current Prefect is Cardinal Gerhard Ludwig Müller.
On 21 July 1542, Pope Paul III proclaimed the Apostolic Constitution Licet ab initio, establishing the Supreme Sacred Congregation of the Roman and Universal Inquisition, staffed by cardinals and other officials whose task it was "to maintain and defend the integrity of the faith and to examine and proscribe errors and false doctrines." It served as the final court of appeal in trials of heresy and served as an important part of the Counter-Reformation.