North Melbourne is an inner suburb of Melbourne, Australia, 2 km north-west of Melbourne's Central Business District. Its local government area is the City of Melbourne. At the 2011 Census, North Melbourne had a population of 11,755.

North Melbourne is bounded by the CityLink freeway to the west, Victoria Street to the south, O'Connell and Peel Streets to the east and Flemington Road to the north. Since July 2008 its local government area has been the City of Melbourne, when it took over the administration of parts of Kensington and North Melbourne that were previously under the City of Moonee Valley, resulting in an increase of approximately 4760 residents and almost 3000 workers (2006 Census).

Formerly known as Hotham, it was essentially a working class area, with some middle class pockets, and was one of the first towns in Victoria to be granted Municipal status.

Today it continues to undergo gentrification, noted for its Victorian architecture, cosmopolitan demographic, commercial and older industrial areas.

North Melbourne's first institutions were built in the 1840s, beginning with a cattle yard. At this time the area was not well defined and included Parkville and Royal Park, as well as a part of West Melbourne.

In the 1850s a Benevolent Asylum was built between Abbotsford and Curzon Streets, coinciding with the desire to find space to accommodate the growing population from the gold rush. (The Asylum remained a feature of the area until its move to Cheltenham in 1911.) In 1859 the area was named Hotham borough, after the governor of Victoria Charles Hotham. Hotham Post Office opened on 20 March 1860.

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