Nodular sclerosis

Nodular sclerosis
Nodular sclerosis. The distinct nodules on the cut surface of this lymph node strongly suggest the diagnosis.
Classification and external resources
Specialty	oncology
ICD-10	C81.1
ICD-9-CM	201.5
ICD-O	M9663/3-9667/3
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Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma that is the most common subtype of HL in developed countries. It affects females slightly more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands.

The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment.

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