"Nobody Wants to Be Lonely" is the second single from Ricky Martin's second English album, Sound Loaded, released on January 16, 2001. Ricky Martin also recorded this single in Spanish entitled "Sólo Quiero Amarte" ("I Only Want to Love You"). Another version of the song was recorded as a duet with Christina Aguilera. This duet version was later included on three of Martin's compilations: The Best of Ricky Martin, 17 and 17: Greatest Hits, and the international version of Aguilera's greatest hits album, Keeps Gettin' Better: A Decade of Hits.

Two music videos were directed by Wayne Isham prior to Christmas in late December 2000, aired on January 15, 2001. One music video is set to the English-language duet 'Nobody Wants to Be Lonely', while the other is set to the Spanish-language solo 'Sólo Quiero Amarte'. The video to 'Nobody Wants to Be Lonely' features Christina Aguilera while 'Sólo Quiero Amarte' shows her in a cameo appearance.

"Nobody Wants to Be Lonely" is one of the first major single releases to not have a commercial CD single in the United States. Although songs had been allowed to chart on the Billboard Hot 100 without single releases since late 1998, (and one song, Aaliyah's "Try Again" had actually hit number one, followed by "Lady Marmalade", which also featured Aguilera) most major single releases by major artists still released singles at the time, especially high-profile songs such as this. With this single being toted as one of the most high-profile duets that year, the music community was then understandably shocked when it was announced that no CD or CD maxi-single would be released for the song.

"Nobody Wants to Be Lonely" peaked at number thirteen on the US Billboard Hot 100, thanks to its top ten peak on the Hot 100 Airplay. The Spanish-language version of the song, entitled "Solo Quiero Amarte", reached number one on the Hot Latin Songs (for four weeks), Latin Pop Songs (seven weeks) and Tropical Songs (two weeks).

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