No Reason (House)

"No Reason" is the twenty-fourth episode and the season finale of the second season of House. It premiered on Fox on May 23, 2006. The episode features creator David Shore's directorial debut.

As House and his team work on the diagnosis of Vincent, a man with a giant swollen tongue and a high temperature, a disgruntled former patient named Jack Moriarty walks into House's office and shoots House twice with a handgun. Vincent develops two additional symptoms: blood leaking into his left eye, causing it to swell outward (and eventually be removed), and a burst testicle. The symptoms appear to have no possible connection to each other.

Waking up from a coma two days later, House continues to treat Vincent from his hospital bed in the ICU with Moriarty, shot by hospital security and handcuffed to his bed, as his roommate. House wakes up Moriarty and asks why he wanted him to die. Moriarty replies that it was not his intention to kill House, and that he wanted to see House suffer. The reason Moriarty wanted to see House suffer was because his wife was a recent patient that House previously treated. While diagnosing her, House badgered Moriarty until he admitted that he had cheated on her. Despite this fact having no medical relevance to his wife's illness, House told her about the affair anyway. Moriarty's wife then committed suicide shortly after being released from the hospital. He tells House that he realizes that his affair led to his wife's suicide, however he feels that House should take part of the blame because there was "no reason" to tell her about it.

Since the shooting, House feels decreased pain in his leg. He finds out from his records that during the surgery to treat the gunshot wounds, a treatment of ketamine to induce a coma had been given to relieve his leg pain, but he experiences neurological side effects. It becomes clear that House cannot separate fact from fiction, as hallucinations begin to get a stronger grasp on his sense of reality, from hitting Wilson to eating tacos outside the hospital. He begins to question his own ability to diagnose, while hostility increases between him and Moriarty. As Vince’s body begins to deteriorate, House struggles through his own self-doubts and must try to make sense of his life and world.

House is seen hallucinating sitting in the passenger seat of Moriarty's wife's car next to her as she commits suicide by carbon monoxide poisoning (by starting her car with the garage door closed). House comes back to his hospital room from his daydreams and with sincerity tells Moriarty "I'm sorry."