Nitrox refers to any gas mixture composed (excepting trace gases) of nitrogen and oxygen. This includes atmospheric air, which is approximately 78% nitrogen, 21% oxygen, and 1% other gases, primarily argon. In the usual application, underwater diving, nitrox is normally distinguished from air and handled differently. The most common use of nitrox mixtures containing oxygen in higher proportions than atmospheric air is in scuba diving, where the reduced partial pressure of nitrogen is advantageous in reducing nitrogen uptake in the body's tissues, thereby extending the practicable underwater dive time by reducing the decompression requirement, or reducing the risk of decompression sickness (also known as the bends).
Nitrox is used to a lesser extent in surface-supplied diving, as these advantages are reduced by the more complex logistical requirements for nitrox compared to the use of simple low-pressure compressors for breathing gas supply. Nitrox can also be used in hyperbaric treatment of decompression illness, usually at pressures where pure oxygen would be hazardous. Nitrox is not a safer gas than compressed air in all respects; although its use can reduce the risk of decompression sickness, it increases the risk of oxygen toxicity and fire.
Though not generally referred to as nitrox, an oxygen-enriched air mixture is routinely provided at normal surface ambient pressure as oxygen therapy to patients with compromised respiration and circulation.
Enriched Air Nitrox, nitrox with an oxygen content above 21%, is mainly used in scuba diving to reduce the proportion of nitrogen in the breathing gas mixture. Reducing the proportion of nitrogen by increasing the proportion of oxygen reduces the risk of decompression sickness for the same dive profile, or allows extended dive times without increasing the need for decompression stops for the same risk. The significant aspect of extended no-stop time when using nitrox mixtures is reduced risk in a situation where breathing gas supply is compromised, as the diver can make a direct ascent to the surface with an acceptably low risk of decompression sickness. The exact values of the extended no-stop times vary depending on the decompression model used to derive the tables, but as an approximation, it is based on the partial pressure of nitrogen at the dive depth. This principle can be used to calculate an equivalent air depth (EAD) with the same partial pressure of nitrogen as the mix to be used, and this depth is less than the actual dive depth for oxygen enriched mixtures. The equivalent air depth is used with air decompression tables to calculate decompression obligation and no-stop times. The Goldman decompression model predicts a significant risk reduction by using nitrox (more so than the PADI tables suggest).