Nissen, von Nissen and von Nissen-Benzon is a Danish family of land owners from Southern Jutland, which was partially ennobled in 1710. It is descended from Henrik Lorentzen (Schack) (born ca. 1450), who in 1484 was granted the estate of Oldemorstoft (a so-called free estate, frigård, i.e. a privileged estate) as a fief by John, King of Denmark. Members of the family were land owners and from the 17th century war commissioners, judges, councillors of state (etatsråd), Governors (stiftamtmann), Supreme Court Justice and General in Denmark. Family members served as Governor of Tranquebar, plantation owner and Vice Governor of the Danish West Indies in the 18th century. In Denmark, the family owned the estates of Oldemorstoft, Lerbæk, Rugballegaard, Brantbjerg, the Stamhus of Skærsø and others between the 15th century and the 18th century. In the 17th century, King Christian IV of Denmark was a guest at Oldemorstoft several times. The name von Nissen was used by the noble branch and military officers of the family.
Herman Lorentz von Nissen was ennobled on 3 November 1710. He was married to Ida Sophie Amalie Glud (1672–1703), daughter of Bishop of Viborg Søren Glud and Ida Christine Moth, a sister of the King's mistress Sophie Amalie Moth. Ida Sophie Amalie Glud was hence a first cousin of King Christian V's son Ulrik Christian Gyldenløve, Count of Samsø. Herman Lorentz' and Ida Sophie Amalie's sons were Christian Ulrich von Nissen-Benzon of Skærsø (1691–1756), Governor of Tranquebar 1720–26 and commandant of Dansborg from 1718, councillor of state, Governor of Trondhjems Stiftamt, Aarhus Stiftamt, Copenhagen, and Supreme Court Justice 1744–56, and Major-General Christian Siegfried von Nissen-Benzon of Skærsø (1690–1763). They inherited the Stamhus of Skærsø from their cousin Sophie Amalia Benzon of Skærsø in 1754. Christian Siegfried von Nissen-Benzon was the father of Christine Sophie von Nissen-Benzon (1734–1772), married to colonel Jacob Ludvig de Vauvert (1727–1809), and their descendants inherited Skærsø. Their grandson Jacob Ludvig Fischer (1776–1833) was ennobled in 1805 and granted the name von Fischer‑Benzon.