Nicholson Street is a street in inner Melbourne. It is named after William Nicholson, then member of the Legislative Council, and later Premier of Victoria from 1859 to 1860.
Nicholson Street runs north-south through inner northern Melbourne. At its southernmost end, it connects to Spring Street near Bourke Street. Between Victoria Parade and Alexandra Parade, it forms the boundary between Carlton and Fitzroy; between Alexandra Parade and Brunswick Road, it forms the boundary between Carlton North and Fitzroy North; north of Brunswick Road, its remaining length is in Brunswick East. Nicholson Street merges into Albion Street, Brunswick East, just north of its intersection with Blyth Street.
Nicholson Street, Brunswick East, is often confused with nearby Nicholson Street, Coburg, which also runs north to south. Nicholson Street, Coburg, is a continuation of Holmes Street, which is itself a continuation of Lygon Street.
Nicholson Street runs from Spring Street in the city, and heads in a north-northeasterly direction for approximately 5 km, before it runs through a series of 3 bends for 500m before merging into Albion Street in Brunswick East, to the north.
Tram route 96 runs along virtually the entire length of the street, entering from Spring Street at the city end and terminating at Blyth Street, just a few hundred metres short of the street's end.