Nicholas III of Saint Omer (died 30 January 1314) was one of the most powerful and influential lords of Frankish Greece. He was hereditary Marshal of the Principality of Achaea, lord of one third of Akova and of one half of Thebes. He also served on three occasions as bailli of the Principality of Achaea (1300–1302, 1304–1307, ca. 1311–14).
Nicholas was the son of John of Saint Omer, Marshal of the Principality of Achaea, and Margaret of Passavant, and the grandson of Bela of Saint Omer, who first received one half of Thebes for his domain from the Duke of Athens (who held the other half). From his father, who died before 1290, Nicholas inherited a third of the Barony of Akova (originally the inheritance of his mother), as well as extensive lands in Messenia and the post of Marshal of Achaea.
He fought in the campaigns of 1291/92 against the Byzantine Greeks of the Despotate of Epirus, and inherited rule over one half of Thebes from his uncle Otho of Saint Omer at his death, sometime before 1299. He was consequently a man of influence in the affairs of Frankish Greece. It was on his advice that Guy II de la Roche, the young Duke of Athens, was wed to the daughter and heiress of Princess Isabella of Villehardouin, Matilda of Hainaut, in an effort to improve the relations of the two most powerful, and often rival, Frankish states of Greece, and establish an alliance between them. In 1300–1302, during Isabella's absence in Italy, Nicholas served as the bailli (representative) of Achaea's suzerain, King Charles II of Naples.