The Neuse River is a river rising in the Piedmont of North Carolina and emptying into Pamlico Sound below New Bern. Its total length is approximately 275 miles (443 km), making it the longest river entirely contained in North Carolina. The Trent River joins the Neuse at New Bern. Its drainage basin, measuring 5,630 square miles (14,600 km2) in area, also lies entirely inside North Carolina. It is formed by the confluence of the Flat and Eno rivers prior to entering the manmade, artificial Falls Lake reservoir in northern Wake County. Its fall line shoals, known as the Falls of the Neuse, lie submerged under the waters of Falls Lake.
Typical of rivers in the Coastal Plain of North Carolina, the Neuse enters a basin of chocolate intermittent bottomland swamp on its journey towards its outlet. One interesting exception is the "Cliffs of the Neuse" area near Goldsboro, where the river cuts a narrow 30 m (90 ft) gorge through limestone and sandstone bluffs. The Neuse is prone to extremes in its flow carriage, often escaping its banks during wet periods, then reducing to a trickle that can be forded on foot during prolonged drought conditions.
The Neuse flows through parts of seven counties. Major cities and towns in proximity to the Neuse are Durham, Neuse Township; Raleigh, the capital of North Carolina; Smithfield; Goldsboro; Kinston; and New Bern.