Nef synthesis

Nef synthesis
Named after	John Ulric Nef
Reaction type	Coupling reaction
Identifiers
RSC ontology ID	RXNO:0000506

In organic chemistry, Nef synthesis is the addition of sodium acetylides to aldehydes and ketones to yield acetylenic carbinols. It is named for John Ulric Nef, who discovered the reaction in 1899.

This process is often erroneously referred to as the Nef reaction. The one properly called the Nef reaction is an unrelated chemical transformation discovered by the same chemist.

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