Neanderthal extinction began around 40,000 years ago in Europe, after anatomically modern humans had reached the continent. This date, which is based on research published in Nature in 2014, is much earlier than previous estimates, and it was established through improved radio carbon dating methods analysing 40 sites from Spain to Russia. The survey did not include sites in Asia, where Neanderthals may have survived longer. In October 2015, studies suggest Neanderthals may have survived even longer, as recently as 24,000 years ago instead.
Hypotheses on the fate of the Neanderthals include violence from encroaching anatomically modern humans, parasites and pathogens, competitive replacement, competitive exclusion, extinction by interbreeding with early modern human populations, and failure or inability to adapt to climate change. Interbreeding took place in western Asia about 50,000 to 60,000 years ago, as evidenced by 1 to 4 percent of genomic material carried by non-African people living today. It is unlikely that any one of these hypotheses is sufficient on its own; rather, multiple factors probably contributed to the demise of an already widely dispersed population.
In research published in Nature in 2014, an analysis of radiocarbon dates from forty Neanderthal sites from Spain to Russia found that the Neanderthals disappeared in Europe between 41,000 and 39,000 years ago with 95% probability. The study also found with the same probability that modern humans and Neanderthals overlapped in Europe for between 2,600 and 5,400 years. Modern humans reached Europe between 45,000 and 43,000 years ago. Most recent numbers based on improved radiocarbon dating indicate that Neanderthals disappeared around 40,000 years ago, which overturns older carbon dating which indicated that Neanderthals may have lived as recently as 24,000 years ago, including in refugia on the south coast of the Iberian peninsula such as Gorham's Cave. Inter-stratification of Neanderthal and modern human remains has been suggested, but is disputed.