Naftifine
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| Clinical data | |
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| Trade names | Exoderil |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a688020 |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C21H21N |
| Molar mass | 287.398 g/mol |
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Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).
Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2–3 days. The metabolites are excreted in the urine and feces.
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