*** Welcome to piglix ***

Mycophenolate

Mycophenolic acid
Mycophenolicacid.svg
Mycophenolic acid ball-and-stick.png
Clinical data
Pronunciation /ˌmkfˈnɒlɪk/
Trade names CellCept, Myfortic
AHFS/Drugs.com Multum Consumer Information
MedlinePlus a601081
License data
Pregnancy
category
  • AU: D
  • US: D (Evidence of risk)
Routes of
administration
Oral,
intravenous
ATC code L04AA06 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 72% (sodium),
94% (mofetil)
Protein binding 82–97%
Metabolism Hepatic
Biological half-life 17.9±6.5 hours
Excretion Urine (93%),
faeces (6%)
Identifiers
CAS Number 24280-93-1 YesY
PubChem (CID) 446541
IUPHAR/BPS 6832
DrugBank DB01024 YesY
ChemSpider 393865 YesY
UNII HU9DX48N0T N
KEGG D05096 YesY
ChEBI CHEBI:168396 YesY
ChEMBL CHEMBL866 YesY
ECHA InfoCard 100.041.912
Chemical and physical data
Formula C17H20O6
Molar mass 320.34 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  
Mycophenolate mofetil
Mycophenolate mofetil2DACS.svg
Mycophenolate mofetil ball-and-stick.png
Clinical data
Trade names CellCept
AHFS/Drugs.com Monograph
License data
ATC code L04AA06 (WHO)
Legal status
Legal status
  • as above
Identifiers
CAS Number 128794-94-5 YesY
PubChem (CID) 5281078
DrugBank DB00688 YesY
ChemSpider 4444535 YesY
KEGG C07908 YesY
ChEBI CHEBI:8764 N
ChEMBL CHEMBL1456 YesY
ECHA InfoCard 100.041.912
Chemical and physical data
Formula C23H31NO7
Molar mass 433.49474 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  

Mycophenolic acid, less accurately called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation. It inhibits an enzyme needed for the growth of T cells and B cells. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability. More recently, the salt mycophenolate sodium has also been introduced. Mycophenolate mofetil is marketed under the trade name CellCept and mycophenolate sodium as Myfortic.

Discovered by an Italian medical scientist Bartolomeo Gosio in 1893, mycophenolic acid was the first antibiotic to be synthesised in pure and crystalline form. But its medical application was forgotten until two American scientists C.L. Alsberg and O.M. Black resynthesised it in 1912, and gave its chemical name. It was eventually found to be a broad-spectrum acting drug having antiviral, antifungal, antibacterial, anticancer, and antipsoriasis properties. The clinically usable drug Cellcept was developed by South African geneticist Anthony Allison and his wife Elsie M. Eugui. It was first approved by the US Food and Drug Administration on 3 May 1995 for use in kidney transplantation.

Mycophenolate is used for the prevention of organ transplant rejection. Mycophenolate mofetil is indicated for the prevention of organ transplant rejection in adults and renal transplant rejection in children over 2 years; whereas mycophenolate sodium is indicated for the prevention of renal transplant rejection in adults. Mycophenolate sodium has also been used for the prevention of rejection in liver, heart, and/or lung transplants in children older than two years. It is also used for retroperitoneal fibrosis along with a number of other medications.


...
Wikipedia

...