"My Babe" is a blues song and a blues standard written by Willie Dixon for Little Walter. Released in 1955 on Checker Records, a subsidiary of Chess Records, the song was the only Dixon composition ever to become a number one R&B single and it was one of the biggest hits of either of their careers.

The song was based on the traditional gospel song "This Train (Is Bound For Glory)", recorded by Sister Rosetta Tharpe as "This Train", a 1939 hit. Dixon reworked the arrangement and lyrics from the sacred (the procession of saints into Heaven) into the secular (a story about a woman that won't stand for her man to cheat): "My baby, she don't stand no cheating, my babe, she don't stand none of that midnight creeping."

Although no documentation exists, the song was probably recorded at Universal Recorders in Chicago, the site of the majority of Chess and Checker sessions until Chess opened their own studio in 1956 or 1957. Backing Little Walter's vocals and harmonica were Robert Lockwood, Jr. and Leonard Caston on guitars, Willie Dixon on double-bass, and Fred Below on drums. Guitarist Luther Tucker, then a member of Walter's band, was absent from the recording session that day. "My Babe" was re-issued in 1961 with an overdubbed female vocal backing chorus and briefly crossed over to the pop charts.

Ray Charles had famously, and controversially, pioneered the gospel-song-to-secular-song approach with his reworking of the gospel hymn "It Must Be Jesus" into "I Got a Woman," which hit the Billboard R&B charts on January 22, 1955, later climbing to the number one position for one week. Within days of the appearance of Charles's song on the national charts, Little Walter entered the studio to record "My Babe" on January 25, 1955. "My Babe" was released while "I've Got A Woman" was still on the charts and eclipsed Charles's record by spending 19 weeks on the Billboard R&B charts beginning on March 12, 1955, including five weeks at the top position, making it one of the biggest R&B hits of 1955. The "B" side of "My Babe" was the harmonica instrumental "Thunderbird," following the pattern established by the release of Little Walter's number one hit single from 1952, "Juke," of featuring a vocal performance one side and a harmonica instrumental on the flip side.

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