Mutsuura Domain (六浦藩 Mutsuura-han?) was a Japanese feudal domain of the Edo period, located in southern Musashi Province in what is now part of Kanagawa Prefecture. Mutsuura was a Fudai domain. It consisted of two separate geographic areas, one in Kuragi District, Musashi, and the other in Osumi District, Sagami, with its headquarters in Musashi in what is now part of Kanazawa-ku, Yokohama. From its location near the famous medieval library of Kanazawa Bunko, it was referred to as Musashi-Kanazawa Domain (武蔵金沢藩 Musashi-Kanazawa-han?) or Bushū-Kanazawa Domain (武州金沢藩 Bushū-Kanazawa-han?) during the Edo period, although the Kanazawa Bunko itself was not within its territory.
In the han system, Mutsuura was a political and economic abstraction based on periodic cadastral surveys and projected agricultural yields. In other words, the domain was defined in terms of kokudaka, not land area. This was different from the feudalism of the West.