Mursili II (also spelled Mursilis II) was a king of the Hittite Empire (New kingdom) c. 1321–1295 BC (short chronology).
Mursili was the third born son of King Suppiluliuma I, one of the most powerful men to rule over the Hittite Empire, and Queen Henti . He was the younger brother of Arnuwanda II, he also had a sister and one more brother.
Mursili is known to have had several children with his first wife Gassulawiya including three sons named Muwatalli, Hattusili III and Halpasulupi. A daughter named Massanauzzi (referred to as Matanaza in correspondence with the Egyptian king Ramesses II) was married to Masturi, a ruler of a vassal state. Mursili had further sons with a second wife named Tanuhepa. The names of the sons of this second wife have not been recorded however.
Through his son Muwatalli he had a grandson who also ruled the kingdom, Mursili III, Queen Maathorneferure and Tudhaliya IV were also grandchildren of Mursili II.
Mursili assumed the Hittite throne after the premature death of Arnuwanda II who, like their father, fell victim to the plague which ravaged the Hatti in the 1320s BC. He was greeted with contempt by Hatti's enemies and faced numerous rebellions early in his reign, the most serious of which were those initiated by the Kaskas in the mountains of Anatolia, but also by the Arzawa kingdom in southwest Turkey because he was perceived to be an inexperienced ruler who only became king due to the early death of Arnuwanda. Mursili records the scorn of his foes in his Annals:
While Mursili was a young and inexperienced king, he was almost certainly not a child when he took the Hittite throne and must have reached an age to be capable of ruling in his own right. Had he been a child, other arrangements would have been made to secure the stability of the Empire; Mursili after all had two surviving elder brothers who served as the viceroys of Carchemish (i.e.: Sarri-Kush) and Aleppo respectively.