Mullens High School was a high school located in Mullens, Wyoming County, West Virginia. It was closed in 1998 after consolidating with nearby Pineville High School to form Wyoming East High School.
Students from nearby Herndon High School had been consolidated into Mullens High School when that school closed in the 1990s.
Mullens High School's mascot was the Rebels and the school colors were blue and gray.
Feeder schools for Mullens High School included Mullens Middle School and Herndon Consolidated Elementary School.